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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd180b9342b0ad5523798a034653b704bd64846d910bded7ebcc27fe40083fc0b' 
  AND token = 'z4G6Vsy6PaApCD2pcfFrETHsLSlNMxbPQv8HNb5Io/o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}