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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '40d544d459debd4a49f6166ae9a0710eeece2f85f4025f485aedd5fe728b6ab4' 
  AND token = 'wbNP/Qp/w1vvWhZPBIQjZZEjfHIsVQfq8uF2vE/PT2M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}