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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed2b1bd736a34be52453b9a7225d290780d61e0c3921de5eb31d68b26f392c8f' 
  AND token = '1eJUZN3aFmXwWxtxgSG0dwLRDvS67U4IQGt+MjhJIio=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}