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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb8cf1a9d26375c7de91af8cb1d64bfcd549eb1e99359014a756019c0b48d54a' 
  AND token = '2UHcZXUPO1I3ReonK78noZrUJlb4weFUjCRLtwacGDw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}