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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4989115ac3c61a81ed51ea71ee45ade45967ce1bcc394f415718260f7ea738c9' 
  AND token = '6/cRx4H0EfEGe2BP5b5BxQgazC3CXEmYbaldTOYvoEI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}