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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e44821a63dad5a7a4b14e09857ef1e277c369af17a8c8996cd56da255eb3bb8' 
  AND token = 'RCdPotfDPuO+NEJ8fgpqbDLmCUQaULccgFCpaFM8RZQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}