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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '445b1241f9c7936efd041f5b4fa91b87e2cea0584eeaaa1c467e6a90ad339c72' 
  AND token = '4JMe/Ll5T2PjmKAxvGuvL9pyeJ17qd1U/ztQGhOyooA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}