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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2122aebc1a3c97751ab9f3c677ee7e12f5aee8282aa5992c3b10feeb23d3628e' 
  AND token = '+T4S0HHSqMGwf/yqAYyfO9gl3GOUwCNQ3cIkfXS/JHA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}