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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12e5c516509c5091f693f12bb7a7fa8ee727453a6189fb3396118a38b6073f33' 
  AND token = 'Zo3eGaBZHDXN/KXqV6yguEcUNvyM6lHaLDop8ZFSTw8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}