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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44ecc974a906921c0c673a54b9bfecaa859b27964c388735e68dee745e782216' 
  AND token = 'iqe0/smRhc6yZjTzmjqTKx8sf7OQUTChzSrYkFTw820=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}