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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '647b49b534b62f659e35429696a97251105c7898ecf54aab9bd9effe01f48dbf' 
  AND token = 'YHthwKAl+LiiEH5RwHxW4s6ILiLN6WAwyk10tX3E9g0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}