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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ae65cdc4368e92aabfc17c526d5545ddd53581ffc7314bc3a408574a2e044113' 
  AND token = 'TC0PagIloXe1Ok4orPWnFc7xW44KQ+GklRgl2V23EPM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}