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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01f1eff1cd27be21517fe807bf3c9be9f3bf1bd9aedcc7d7664733cc9528d730' 
  AND token = 'ARveKGEiVsfTRV9kE+dJEBtrLt8OSyAH9aeiEDgQEA4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}