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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8d106a85acffe28838361fe35244ae002fbf595da607089be49345e81ce5c14' 
  AND token = 'V+vj3iacdx4D3enDwiZ/DbdGQAsHoZcN0ARYybl9OZg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}