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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22a30ebabc679cdf1ee3960789d1298c43a5bf22fbb5907f95d0a2e3b5129f4a' 
  AND token = 'NPQuHfylHL2JFBG++Fw7sieV0eNmXQi+0ts/9nkHrnY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}