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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '86f0dc503bd3e480a8405c0b4337254227b2534066b7855850ff3c4e4eda7b97' 
  AND token = 'EeDpL2CBEPmPXEI5FTIxsiEsw5d0OCQSBa+FAPzCssU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}