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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c48fc980288e330d681893dd83845be7eb28fbbad0f2099f29127d03f06eb6a7' 
  AND token = 'vrp0IYE7K/6YqHdxYafQujwFAt2y4n2rUHvEt11LUFY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}