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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a25fc5b416eaae76263793d045586812ea068ac52cac8044b0c829037933dbbd' 
  AND token = '8MkmzUJBlx3Hk/7rPfHC8tXD+L9zvLOtY4yu8hO5IrU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}