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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c6d454566787632399c3106c2fde40b4b9d8b53101e46d2d56b3b02ac5715ce3' 
  AND token = 'xEdTSFJLYyBB8wWT1TkrKxBxjuYUD4GcWM/45dz0Kr8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}