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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22106c29b1d59424db151db596fd4f40b79658c338785f5bc48bc2c365777742' 
  AND token = 'AuaAB2xGOS5/kZW5BXW9UMNBp8+Nfh70Zmfv/SZMcCE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}