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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '17f9a0fde3e2e3221a8bc65f279b531bce46b2038c2e2072dd34d25264cd8441' 
  AND token = 'AEtB6rTS8vCBm4eq03ecsLkkdD8DtKhUtQoMS7jaWII=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}