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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21ff2aac6cd798164710624d6c97b240f8d25fbb78b154adcb9493a335bde88b' 
  AND token = 'XaJoFgpDzNeXCooBWToR8xj6QzpLCIzbOyB2qY+4Akc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}