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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00d5725116ecf1354edac5762922149fb89e835e7f58adad5547f23450bca171' 
  AND token = 'S29V55e1wYni5hY2IiNhWqphz6n6eVDmZCtsEb4tqco=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}