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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45dd4d215f91751d350e8e299baa84ab466f3fceef96fba0103d16b763dcb55d' 
  AND token = 'O3S6Jfc3d9dMb8r8+pWPa12mkwbwwXR1wV1QvhSgNaw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}