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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '37d8d8f366d3a797b3312e50eb8edc724b6f2274541b62ff2f7e24a7a7a24c00' 
  AND token = 'Oo/ESJO/rmbXoHe3tOtiBphfBPEYymk9JURr3FuGLrQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}