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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a802680639f32049b2f7ea1ada3cb7660bf3061ca2475e04506b56de3602c06' 
  AND token = 'LuAotS1AcTpjBAy+roJfRwnnT2K477/uyhhKEXXpxSM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}