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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c42e61996a16568183f3ee3e7c39ef8f7168f3518412f8b1654c0ec54fef725' 
  AND token = 'YcuUXA7DhxobkxmHBPOPtfV4tmfB3kix2UJwJoV0aYI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}