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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed6f0d374d76d3223409117449072cb1d734b797aaa45b64dfde7a27795d63b3' 
  AND token = 'eAfW9eTKW1/pqdOCPPsJVKHs6uHUHY1rzQwl25+KWzI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}