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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ffefe5d6f36db8d433eace942d8ac54e367ff8fda7a9d5740d33d4dd61da0cec' 
  AND token = 'icPq/v7r1xQV6qIAaExv1I30dtwgdH9lVOO9Ro1WYgo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}