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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '251ce1d31045a3b53807d5675a4dfaa092fd8ca6bd6c7e07641141e96e4f3f64' 
  AND token = 'Kecm8aIecLZRcRa671IMmZkMQhCf0wh8YzTzzlhOU9M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}