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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c16bbfa5a227294a54674ef180908af81227d8560f88b54d3e224962c5584f3' 
  AND token = 'St2kHtlFxzIezBjBZXNb/PFeM/4rEgeYahLeMyz5TkU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}