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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd274628302a6da2a4045e5daae48ef56b2dbcdf7a28b3baf76e81cd9d44443d4' 
  AND token = 'HmSgPAFW+hA/TXIfd6KM25F6NhqC7lrrPSpE9u8QIwM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}