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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '126879e1f7ce45f5c3c7fb6cd8d10825762e416291518e017dcf7cf453e26ed5' 
  AND token = 'cEEMCkFO1HGDGTUs1APrSAFr2K9HgGIw1HWdTE4xA6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}