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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b81c46b9caaf1eb4501478a720f9391c1e92508020279c87276c834cc737fd6d' 
  AND token = 'HUL3DTMqjoF4mR8Zm9oQgVXtUFjV5hy4cLNmntsi+Go=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}