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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d461efb62d19f9256245a4e721c9cd4eed90300f2d56a22d25f27f1f29e92de' 
  AND token = '5/kqMYZfEQMQtd4xWBaOIMOSCdeSPfi2m7ZWT87vBhM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}