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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e6d1168fd56a61c902a9a4b54bf643e0000d19b19071a5bb80b5b1a66a041e01' 
  AND token = 'PgWBuycM6JMF+ZvsJb7N/wUATu7oXYyOASLfT9CiZD8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}