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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd6877e33e49a7021aaa50caa9dd4bce1779c434c09749ced2b33220ed2edff60' 
  AND token = '8yQiOGp6kX99s8vMPMt+29xhBiMrS3CUOqHa9CEpCig=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}