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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5381d52d91a41b72bec9c62259daf6036be824a55f35bb5148230b43feea2935' 
  AND token = 'YNJFsqjrrFcVGPS/M89dRfSwVJAYOG3W/2nt68Luq14=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}