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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21612601fd6644c6adaeacd2d66f6b4b32bc0b75fd27995bb965e2f8fbd5f6e7' 
  AND token = 'tXTFjwLW1qM59F5ZtcM1U/QAWwQria73sTsyYbu+IBU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}