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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1604fc44c8c82998eaa602f629fc325825a0f86453cdc0e50ce1c5388a5d6df9' 
  AND token = 'PtqFWG+FTez1jdFsJIQMRSPEur9tTVYhOFhw1dHgW5c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}