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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de0749e9f93a4ff8ff935ec90a155732e29b58b3d476712bf4b0169e96d285e8' 
  AND token = 'Dp2/b7b2QS0XBk4gkyeLrNeJtS+2o92GWmUVXWsQnKM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}