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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33d165fb9f45aec1bfbaccb2cba3f8bb37da40b2226847e8f4fea968cbcb1257' 
  AND token = 'XDZcEXV3Zm+fqIj265r7gT3sSQW+kpdqs4yj1KcfqU0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}