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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8de00e7050b3db7d23c071fa9421a04ea140e5f90224f343ccd27c1d48bfc597' 
  AND token = 'PqFcqPXLdJez9GoG8oHzenTHdQTHvLHX75PPPTTb9Js=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}