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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '601c4bf7fb883706f1990a232743c937b3db7f007091e9221d06db9f361c7090' 
  AND token = 'upV4TqNWW7Qcc6LLL8ZUYuReFYfmwJYyWipBNEC9WoM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}