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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1f6487bfe6c26d51dc7664bcbc40cf0cbc946aa00dd1067ebb3699045865a19f' 
  AND token = 'zi3RnjQmMUFi1xsR+dH+eHt4nXmi2qWnhyUX4a5tNeE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}