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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce0417b07bae6f05366ccfdc4525494f6b74af1b69df297a8712c48c299259d6' 
  AND token = 'tRvm0L8mgXKgBdhwMuEVRz4G0TpLuIXLRRbHU4YD6b4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}