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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e394c27cada4ce321ccf607e26f548c8fb36d55e8e10910402f9cce2436a690' 
  AND token = 'BMQGd1fOk+OtRDipejQLEfnHb1hkrLPGwfGcmnp/Gd8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}