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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7a172994ddd5a40305c4bac184b87eb42793b4f024c34b86f87e8fbedbb1c8b9' 
  AND token = 'IouXLOzjIUIn/d9cIC7zlIZS60jLc9O1c8iQ4dsyVUc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}