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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74429464d8045b08d20ee56ce7fd3aa1c47c65ca2683c0d4a62b0684f0bd5222' 
  AND token = 'HNbd7HU1THFZv3R552A3TWzbNNitCFBkN1HSPlotnE0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}