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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e8a70f23b568e2cfc74d16bb550a79abe967e99c0b9d11720cc69ef436fafd5' 
  AND token = 'QFC1TX2iHr1tnV3OFCE6kW3phWXpLrfGYr9uX6q77Jo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}